Assignment: Neural Communication

Any and all behaviors originate in the nervous system. If you are reacting to a mosquito biting your arm, sensory receptors in your skin detect the insect in a specific place on your arm. They send that information to the brain using a combination of electrical and chemical signals. Your brain receives that information and reacts to it, generating a motor response. This plan is transmitted back to the muscles of the arm, again using a combination of electrical and chemical signals. Likewise, any other behaviorfrom a memory of your childhood to the emotional reaction to a movie to the decisions about what to have for dinner tonightis controlled by electrical and chemical messages exchanged by neurons in your nervous system.

Damage to the nervous system will affect its behavior. If a person has a stroke in the motor cortex, there will be impairments in his or her ability to move part of their body. In some cases of a traumatic brain injury, a persons brain collides with the inside of the skull. This may tear neurons and cause swelling, which will change how the brain functions in both the short term and the long term. An injury to the spinal cord can result in paralysis. While the brain is exceptionally complicated, researchers are starting to identify ways to minimize or reverse such damage to the nervous system, such as the use of brain-machine interfaces.

In this Assignment, you will consider both the normal electrical and chemical signaling that occurs in the brain and damage that can affect the nervous system. In the first half of your Assignment, you will describe in detail how the neurons of the brain use electrical and chemical signals to collect and transmit information. Then, in the second half, you will be assigned a topic based on the first letter of your last name. You will find a recent research article (published within the past 3 years) that addresses the neuroanatomy, neurophysiology, recovery of function following injury, or a new treatment for your assigned topic. You will summarize your article describing what the researchers did and relating their work back to what you have learned about the anatomy and physiology of the nervous system from the course textbook.

To prepare for this Assignment:

• Review Chapter 2 of the textbook, focusing on how information is transmitted through the nervous system.
• Review Chapter 3 of the textbook focusing on where different functions are localized in the brain.
• Choose one of the articles out of the two listed below for each category (the category assignment is based on your last name; you only need to read and report on ONE article in total) and then download the full PDF from the Walden Library (the articles have been pre-selected for you and cover topics such as neuroanatomy, neurophysiology, recovery of function, or novel treatments associated with one of the following conditions). You may choose your own article; however, it must be approved by your instructor by Thursday before the assignment is due.

Last name AG: Stroke

• Daily repetitive sensory stimulation of the paretic hand for the treatment of sensorimotor deficits in patients with subacute stroke: RESET, a randomized sham-controlled trial

OR

• The effects of Nintendo Wii-based balance and upper extremity training on activities of daily living and quality of life in patients with sub-acute stroke: a randomized controlled study

Last name HM: Traumatic brain injury

• The efficacy of prospective memory rehabilitation plus metacognitive skills training for adults with traumatic brain injury: study protocol for randomized controlled trial

OR

• Tonic and phasic alertness training: a novel treatment for executive control dysfunction following mild traumatic brain injury

Last name NS: Brain machine interface to address trauma or loss of function

• Engineering Artificial Somatosensation Through Cortical Stimulation in Humans

OR

• A new therapeutic application of brain-machine interface (BMI) training followed by hybrid assistive neuromuscular dynamic stimulation (HANDS) therapy for patients with severe hemiparetic stroke: A proof of concept study

Last name TZ: Spinal cord trauma

• Bone architecture adaptations after spinal cord injury: impact of long-term vibration of a constrained lower limb

OR

• A new therapeutic application of brain-machine interface (BMI) training followed by hybrid assistive neuromuscular dynamic stimulation (HANDS) therapy for patients with severe hemiparetic stroke: A proof of concept study

The Assignment (34 pages):

• First, describe how information is transmitted through the nervous system. Starting with the dendrites, how does the signal from the previous neuron enter the neuron? How is it integrated? How is information transmitted from the cell body to the presynaptic terminal? How does information leave one neuron to carry the signal to the next neuron?
• Then, identify and explain the neurobiology (anatomy and physiology) of your specific topic. What parts of the brain are affected by your assigned injury or trauma? What are the potential manifestations of the trauma based on the location of the injury or trauma? Information on each condition can be found both in your textbook and from outside sources.
• Summarize the article you selected. Provide enough detail that your reader can understand the article and talk about it to someone else, similar to what you saw in the articles from BioPsychology.com in this weeks Discussion. What did the researchers do in their study? Were they attempting to understand the neurobiology of the condition, measuring the recovery of function after the injury, or testing out a new treatment?
• Explain how the article you read extends your knowledge of this topic from what was described in the textbook.

Support your Assignment with specific references to all resources used in its preparation. You should include in-text citations in the body of your Assignment as well as complete references in APA format at the end of your Assignment.