A coenzyme is a cofactor. A loosely bound cofactor is a coenzyme and a tightly bound cofactor is a prosthetic group. Cofactors are non-protein “helper” molecules that can be classified as organic or non organic ( sometimes restricted to inorganic substances only). Organic molecules are either vitamins or made from vitamins like the <a href=”https://naturesblendshop.com/”>vitamins B1</a> , B2, B3, B5, B6 and Biotin. Inorganic cofactors are usually metal ions like Mg2+